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Nat Rev Gastroenterol Hepatol 11(5):317–328īurns AJ, Roberts RR, Bornstein JC, Young HM (2009) Development of the enteric nervous system and its role in intestinal motility during fetal and early postnatal stages. Neurogastroenterol Motil 16(Suppl 1):34–38īurns AJ, Thapar N (2014) Neural stem cell therapies for enteric nervous system disorders. Development 130(25):6387–6400īornstein JC, Costa M, Grider JR (2004) Enteric motor and interneuronal circuits controlling motility. J Comp Neurol 522(3):514–527īondurand N, Natarajan D, Thapar N, Atkins C, Pachnis V (2003) Neuron and glia generating progenitors of the mammalian enteric nervous system isolated from foetal and postnatal gut cultures. J Physiol 590(Pt 3):533–544īergner AJ, Stamp LA, Gonsalvez DG, Allison MB, Olson DP, Myers MG Jr, Anderson CR, Young HM (2014) Birthdating of myenteric neuron subtypes in the small intestine of the mouse. Dev Biol 132(1):189–211īaudry C, Reichardt F, Marchix J, Bado A, Schemann M, des Varannes SB, Neunlist M, Moriez R (2012) Diet-induced obesity has neuroprotective effects in murine gastric enteric nervous system: involvement of leptin and glial cell line-derived neurotrophic factor. This process is experimental and the keywords may be updated as the learning algorithm improves.īaetge G, Gershon MD (1989) Transient catecholaminergic (TC) cells in the vagus nerves and bowel of fetal mice: relationship to the development of enteric neurons. These keywords were added by machine and not by the authors. Here, I will discuss recent advances in knowledge about postnatal development of the murine ENS, and highlight future directions for this emerging research field. Notably, due to the availability of mouse models for several human enteric neuropathies, many studies have used the mature and developing murine ENS as a model. Researchers have used a variety of animal models that are easy to manipulate genetically or experimentally, and have short gestational periods, to understand the development of the ENS. However the genetic and environmental factors that regulate postnatal ENS development remain unknown.
Thus it is possible that manipulating certain environmental factors could help prevent or reduce motility disorders. During postnatal stages, in addition to genetic influences, ENS development is also potentially affected by the external environment. On the other hand, it has only just become clear that a substantial process of ENS maturation occurs after birth (Hao et al. Owing to over three decades of research, we now have a good understanding of the genetic and molecular control of enteric nervous system (ENS) development during embryonic and prenatal stages.
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